Our recent paper titled “Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization”, is now available online in Cell Reports by Cell Press, featured in the November issue (Vol 43, Issue 11).
Boutou et al., show that highly activated inflammatory microglia mediate remyelination in a cortical demyelination model and identify microglia sensing of solTNF through TNFR1 as an immune checkpoint in the polarization between reparative and damaging microglia with potential therapeutic relevance for CNS demyelination.
This research was performed in the Probert lab, Laboratory of Molecular Genetics, Hellenic Pasteur Institute Athens, Greece, in collaboration with Imperial College London, UK; DIANA lab, Hellenic Pasteur Institute, & University of Thessaly, Greece ; Center for Brain Research, Medical University of Vienna, Austria & INmune Bio Inc., USA.
DOI: 10.1016/j.celrep.2024.114894
